1. Higher
adhesive force between breast cancer cells and MSCs, as compared with
HSPCs, assessed by quantitative atomic force microscopy-based
single-cell force spectroscopy could partially account for tumor cell
mediated reduction in HSPC adhesion to MSCs.
2.. The
K8-null mouse models also provide novel epithelial-derived robust
colon-specific CRC models.
3. Therefore,
targeting this cross talk may represent a novel therapeutic strategy.
4. To
this end, we established two models of competitive cell
adhesion—simultaneous and sequential—to study a potential
competition for homing to the niche and displacement of the
endogenous HSPCs upon invasion by tumor cells.